Sub-nanometer resolution structure of the intact T. thermophilus H+-driven ATP synthase. 5207-1 King’s College Circle John Rubinstein obtained his B.Sc from the University of Guelph in 1998. John E. Walker (1,121 words) exact match in snippet view article find links to article needed] Mark Van Raaj, Postdoctoral Fellow (CNB Spain)[citation needed] John Rubinstein, PhD student (Toronto)[citation needed] Matti Saraste, Postdoctoral Background in Physics, Chemistry, Biology, or Computer Science? He received his PhD from Cambridge University (2002) where he worked in Medical Research Council laboratories under the supervision of … This reduction in the temporal resolution of the camera requires decisions to be made during data acquisition that may result in the loss of information that could have been advantageous during image analysis. Biochemistry; Biophysics; Computer software; Enzymes; Information and communication services; Physics; Associated Researchers. Our group studies the structure and function of macromolecular assemblies using electron cryomicroscopy (cryo-EM), image analysis, molecular biology and molecular genetics. Protein homeostasis is critically important for cell viability. John Rubinstein Contact via University of Toronto Key Research Areas. This week's Theater Stories features the Longacre Theatre! See search results for "John Rubinstein" in the Toronto Public Library digital collection. 686 Bay Street, Rm. He is the youngest of four children. He received his PhD from Cambridge University (2002) where he worked in Medical Research Council laboratories under the supervision of Sir John E. Walker and Dr. Richard Henderson. Enigma Variations, starring Donald Sutherland and John Rubinstein will be opening again, but not on Broadway -- not quite yet, anyway. 3 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada. David Mark Rubenstein (born August 11, 1949) is an American billionaire businessman and philanthropist. Home. He received his PhD from Cambridge University (2002) where he worked in Medical Research Council laboratories under the supervision of Sir John E. Walker and Dr. Richard Henderson. John Rubinstein is an American actor who portrays Daniel Webster on Netflix's Chilling Adventures of Sabrina. Dr. John Rubenstein A former financial analyst and lawyer, he is a co-founder and co-executive chairman of American private equity firm The Carlyle Group, a global private … Toronto, Ontario M5S 1A8 Who we are. Temerty Faculty of Medicine, University of Toronto © 2021 University of Toronto, Faculty of Medicine, University of Toronto, Princess Margaret Cancer Research Tower, MaRS Centre, Image-Guided Therapy and Device Development, Mental Health Information for MBP Faculty, 1) Novel Quantification of BOLD f-MRI Cerebrovascular Reactivity 2) Predicting Recurrence in DCIS Using Convolutional Neural Networks, 1) Development of PROteolysis-TArgeting Chimeras (PROTACs) for targeted degradation of NSD2 in cancer 2) Signal transduction pathways regulating neuroblastoma metastasis, 1) A Variational Network for Joint MRI Reconstruction and Head Motion Correction 2) Automatic Grading of Nuclear Pleomorphism in Ductal in situ Carcinoma, 1) BOLD MRI in Fetal Growth Restriction 2) An objective method for estimating tumour-stroma ratio using quantitative polarized light microscopy, PhD Oral Examination for Ms. Sujun Chen - The Transcriptomic Heterogeneity in Prostate Cancer. CryoEM map of the mycobacterial ATP synthase with the TB drug bedaquiline. Contact. john.rubinstein@utoronto.ca. 686 Bay Street, Toronto Toronto, ON M5G0A4 John Rubinstein obtained his B.Sc from the University of Guelph in 1998. John Rubinstein Picture Gallery on BroadwayWorld.com with John Rubinstein Photos from stage, special events, red carpets and more. Lab: Tel 416-813-7654 ext. The ABC core structure is comprised of two transmembrane domains (TMD1 and TMD2) and two cytosolic nucleotide binding domains (NBD1 and NBD2). One of four siblings (along with Eva, Paul, and Alina) born to Jewish piano virtuoso Arthur Rubinstein (Artur Rubinstein) and his Catholic wife, Nela Kon (born Aniela Mlynarska), John Rubinstein has one daughter and four sons (Jessica Katz, Michael Weston, Peter Rubinstein, Jacob Rubinstein, and Max Burgess-Rubinstein) and three grandchildren. John Rubinstein obtained his B.Sc from the University of Guelph in 1998. BACKGROUND: Proteins, which are long chains of chemical building blocks (amino acids) that can fold up to take on precise 3-D structures, are responsible for most of what happens in a living cell. John Rubinstein is an actor, director, composer, singer, and teacher. peterb@dbb.su.se. A high ratio of camera frame rate (frames per second) to camera exposure rate (electrons per pixel per second) allows electron counting, which further improves the DQE and enables the recording of super-resolution information. 7 Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada. The primary purpose of this dedicated webpage is to disseminate original software for computational analysis of cryo-EM images.  This software is provided as source code and is without any guarantee of support. Once again, the depths of the criminal mind and the darkest side of a glittering city fuel #1 New York Times bestselling author Jonathan Kellerman's brilliant storytelling. This format enables the recording of DDD movies at the raw camera frame rate without sacrificing either spatial or temporal resolution. Research Opportunities for Trainees with a Background in: Biophysics and Biomolecular Interaction Centre, Additional Toronto-based Technology Centres, Comprehensive List of Biochemistry Instrumentation. This process usually occurs at the level of developing new algorithms and software for image analysis and performing calculations with images and models of molecular structure. He was born in Los Angeles, California in 1946, the same year his father, the renowned Polish-born concert pianist Artur Rubinstein, became an American citizen. c. Department of Medical Biophysics, The University of Toronto, 101 College Street, Toronto, Ontario, Canada M5G 1L7 . April 2013 My most recent project, "Lost!Leveraging the Crowd for Probabilistic Visual Self-Localization" with Andreas Geiger and Raquel Urtasun, has been accepted for an oral presentation at CVPR 2013.See the project website for the video and paper. Movie output also allows the correction of specimen movement and compensation for radiation damage. Links. Atomic model for the dimeric FO region of mitochondrial ATP synthase.Hui Guo, Stephanie A Bueler, and John L Rubinstein(2017) Science 358, 936-40. cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination.Ali Punjani, John L Rubinstein, David J Fleet, and Marcus A Brubaker(2017) Nature Methods 14, 290-6. John L. Rubinstein 1, 2, 3; 1 Molecular Structure and Function Program, Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada. b Molecular Medicine program, The Hospital for Sick Children, 686 Bay Street, Toronto, Ontario, Canada M5G 0A4 . MBP scientist Dr. John Rubinstein and a group of research collaborators have published a new International Union of Crystallography Journal article entitled 'Electron-event representation data enable efficient cryoEM file storage with full preservation of spatial and temporal resolution'. Experimental data demonstrate that the method retains super-resolution information and allows the correction of specimen movement at the physical frame rate of the camera while maintaining manageable file sizes. 20-9400T. 8 Department of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden. Our group, consisting of biophysicists and biochemists, studies the structure and function of macromolecular assemblies using electron cryomicroscopy (cryo-EM), image analysis, biochemistry and molecular genetics. The Rubinstein Laboratory. Rm. Canada The EER format will enable the development of new methods that can utilize the full spatial and temporal resolution of DDD cameras.'. Article Abstract'Direct detector device (DDD) cameras have revolutionized electron cryomicroscopy (cryoEM) with their high detective quantum efficiency (DQE) and output of movie data. Medical Sciences Building He was born in Los Angeles, California in 1946, the same year his father, the renowned Polish-born concert pianist Artur Rubinstein, became an American citizen. He was born in Los Angeles, California in 1946, the same year his father, the renowned Polish-born concert pianist Artur Rubinstein, became an American citizen. john.rubinstein@utoronto.ca. Dr. Rubinstein was a Post-doctoral Research Associate at the MRC Laboratory of Molecular Biology before returning to Canada for a National Cancer Institute of Canada (… 416-978-6892, Copyright 2019 Department of Biochemistry, University of Toronto | All Rights Reserved. We also study bacterial toxins that interact with mammalian cells. Read the full article on the IUCr Journal website. Dr. John L. Rubinstein 416-813-7255 john.rubinstein@utoronto.ca Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPaseJianhua Zhao, Samir Benlekbir, and John L. Rubinstein(2015) Nature 521, 241-5. (8)Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; john.rubinstein@utoronto.ca kay@pound.med.utoronto.ca. Recent biological projects have included the structural study of the mitochondrial ATP synthase, the Vacuolar-type ATPase, and the V/A-ATPase. He received his PhD from Cambridge University (2002) where he worked in Medical Research Council laboratories under the supervision of Sir John E. Walker (Nobel Prize for Chemistry, 1997) and Dr. Richard Henderson (Nobel Prize for Chemistry, 2017). Publications. Some members of the C-subfamily of ABC (ABCC) proteins, including human multidrug resistance proteins (MRPs), also possess an N … (4)Program in Molecular Structure & Function, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada. P. Lynne Howell's 212 research works with 5,857 citations and 8,731 reads, including: A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa Photos. 20-9705 Peter Gilgan Centre for Research and Learning The Hospital for Sick Children 686 Bay Street, Toronto. BSc, University of Guelph, 1998PhD, Cambridge University, 2002. (3)Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada. ATP binding cassette (ABC) proteins typically function in active transport of solutes across membranes. 1/16. Fabrication of carbon films with ~500 nm holes for cryo-EM with a direct detector device.Chelsea R. Marr, Samir Benlekbir, and John L. Rubinstein(2013) Journal of Structural Biology 185, 42-7. 3 Molecular Medicine Program, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada. John Rubinstein, Actor: Family. d. Department of Biochemistry, The University of Toronto, 1 Kings College Circle, Toronto, Ontario, Canada M5S 1A8 Alignment of cryo-EM movies of individual particles by optimization of image translationsJohn L. Rubinstein and Marcus A. Brubaker(2015) Journal of Structural Biology 192, 188-95. Mycobacterial ATP synthase with bedaquiline. john.rubinstein@utoronto.ca. Biochemistry Graduate Student Union (BGSU), Biochemistry Undergraduate Student Society (BUSS), Department of Biochemistry 100th Anniversary Symposium, Wellness and Equity, Diversity and Inclusion (WIDE), dedicated webpage is to disseminate original software for computational analysis of cryo-EM images, BCH 2024H Intro to X-ray crystallography and electron cryomicroscopy, BCH473Y Advanced Research Project in Biochemistry, BCH425H Structural Biology: Principles and Practice, Stephanie Bueler, MSc (Research Project Coordinator), Samir Benlekbir, PhD (Microscopy facility manager), Justin Di Trani, PhD (Postdoctoral fellow). It is common practice to sum groups of successive camera frames to reduce the final frame rate, and therefore the file size, to one suitable for storage and image processing. However, these movies come at the cost of producing large volumes of data. Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase.Mohammad Mazhab-Jafari, Alexis Rohou, Carla Schmidt, Stephanie A Bueler, Samir Benlekbir, Carol V Robinson, and John L Rubinstein(2016) Nature 539, 118-22. Dr. Rubinstein was a Postdoctoral Research Associate at the MRC Laboratory of Molecular Biology before returning to Canada for a National Cancer Institute of Canada (NCIC) postdoctoral fellowship at the Banting and Best Department of Medical Research. John Rubinstein is an actor, director, composer, singer, and teacher. Wilson Lau and John L. Rubinstein(2012) Nature 481, 214-8. john.rubinstein@utoronto.ca. He is the youngest of four children. Here, experimental analysis of a new electron-event representation (EER) data format for electron-counting DDD movies is presented, which is enabled by new hardware developed by Thermo Fisher Scientific for their Falcon DDD cameras. 2 Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford OX1 3QZ, UK. JOHN RUBINSTEIN Professor, University of Toronto John Rubinstein obtained his B.Sc from the University of Guelph in 1998. Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8 Canada. Toronto, ON M5G0A4 August 1, 2020 shopify theme selection. john rubinstein toronto. We also develop the tools of cryo-EM so that we can answer questions that are not amenable to the techniques that currently exist. 2014-2021 — Canada Research Chair in Electron Cryomicroscopy (Tier I) 2014 — GE Healthcare New Investigator Award (Canadian Society for Molecular Biosciences) 2013 — Burton Medal (Microscopy Society of America) 2009-2014 — Early Researcher Award 2007-2012 — CIHR New Investigator Award, BCH 2024H Intro to X-ray crystallography and electron cryomicroscopyBCH473Y Advanced Research Project in BiochemistryBCH425H Structural Biology: Principles and Practice. Search for more papers by this author 2 Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada. John Rubinstein is an actor, director, composer, singer, and teacher. 306154. 4 Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. More. He is the youngest of four children. He joined the Research Institute of The Hospital for Sick Children in 2006 and is a Professor in the Departments of Biochemistry and Medical Biophysics. John Rubinstein obtained his B.Sc from the University of Guelph in 1998. People. Learn about the shows to have graced the theater's stage including A Bronx Tale, … And no one conducts a more harrowing and suspenseful manhunt than the modern Sherlock … Program in Molecular Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada. Research. Department of Molecular Genetics and Chemistry, University of Toronto, Toronto, Ontario, M5S 1A8 Canada. 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